Chiung-Mei Chen Selected Research

polyglutamine

2/2024	Investigating the therapeutic effects of novel compounds targeting inflammatory IL-1β and IL-6 signaling pathways in spinocerebellar ataxia type 3.
1/2023	Amyloid modifier SERF1a interacts with polyQ-expanded huntingtin-exon 1 via helical interactions and exacerbates polyQ-induced toxicity.
11/2020	Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation.
1/2020	New Synthetic 3-Benzoyl-5-Hydroxy-2H-Chromen-2-One (LM-031) Inhibits Polyglutamine Aggregation and Promotes Neurite Outgrowth through Enhancement of CREB, NRF2, and Reduction of AMPKα in SCA17 Cell Models.
9/2019	Focused ultrasound-induced blood brain-barrier opening enhanced vascular permeability for GDNF delivery in Huntington's disease mouse model.
1/2019	Targeting Ubiquitin Proteasome Pathway with Traditional Chinese Medicine for Treatment of Spinocerebellar Ataxia Type 3.
1/2019	Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models.
1/2018	The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice.
12/2017	Down-regulation of miR-9* in the peripheral leukocytes of Huntington's disease patients.
11/2017	Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum.

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Chiung-Mei Chen Research Topics

Disease

40	Parkinson Disease (Parkinson's Disease) 01/2024 - 02/2004
24	Huntington Disease (Huntington's Disease) 07/2023 - 12/2003
22	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 02/2024 - 10/2008
20	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2024 - 01/2013
20	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 05/2007
10	Neuroinflammatory Diseases 02/2024 - 01/2018
10	Inflammation (Inflammations) 11/2023 - 08/2014
7	Disease Progression 07/2023 - 01/2019
7	Cerebral Hemorrhage 01/2022 - 10/2009
7	Dementia (Dementias) 01/2022 - 01/2007
6	Polyneuropathies (Polyneuropathy) 12/2023 - 10/2017
6	Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) 11/2022 - 05/2007
6	Multiple Sclerosis 10/2020 - 01/2009
6	Guillain-Barre Syndrome 01/2018 - 05/2007
5	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 02/2024 - 01/2013
4	Neuromyelitis Optica (Devic's Disease) 05/2024 - 02/2013
4	Neuroblastoma 11/2021 - 01/2009
3	Cognitive Dysfunction 04/2023 - 01/2022
3	Tauopathies 10/2022 - 01/2016
3	Cerebellar Ataxia (Dysmetria) 01/2022 - 12/2014
3	Hemorrhage 01/2022 - 01/2015
3	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 12/2021 - 12/2003
3	Stroke (Strokes) 01/2018 - 10/2012
3	Parkinsonian Disorders (Parkinsonism) 01/2018 - 03/2010
3	Miller Fisher Syndrome (Fisher Syndrome) 10/2016 - 01/2009
3	Diabetes Mellitus 10/2012 - 05/2007
2	Venous Thrombosis (Deep-Vein Thrombosis) 07/2023 - 01/2006
2	Atrial Fibrillation 01/2022 - 01/2022
2	Ischemic Stroke 01/2018 - 09/2015
2	Wernicke Encephalopathy (Wernicke's Encephalopathy) 12/2017 - 10/2017
2	Atrophy 06/2014 - 10/2004
2	Mitochondrial Diseases (Mitochondrial Disease) 06/2014 - 03/2011
2	Essential Tremor (Essential Tremors) 08/2013 - 01/2011
2	Hypertension (High Blood Pressure) 10/2012 - 12/2011
2	Spinocerebellar Ataxia 17 01/2012 - 02/2009
2	Viral Meningitis 07/2009 - 05/2007

Drug/Important Bio-Agent (IBA)

24	polyglutamineIBA 02/2024 - 02/2009
20	Proteins (Proteins, Gene)FDA Link 02/2024 - 12/2003
13	Biomarkers (Surrogate Marker)IBA 12/2023 - 02/2015
11	SynucleinsIBA 01/2024 - 01/2013
11	TATA-Box Binding Protein (TATA-Binding Protein)IBA 01/2020 - 02/2009
10	tributyl phosphate (TBP)IBA 01/2020 - 10/2005
8	Brain-Derived Neurotrophic Factor (BDNF)IBA 05/2023 - 03/2007
7	Amyloid (Amyloid Fibrils)IBA 01/2022 - 10/2018
5	Interleukin-6 (Interleukin 6)IBA 02/2024 - 10/2016
5	indoleIBA 11/2023 - 10/2014
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2022 - 04/2007
4	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2024 - 01/2014
4	LipidsIBA 01/2023 - 10/2009
4	tau Proteins (tau Protein)IBA 01/2021 - 01/2016
4	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2019 - 08/2009
4	CholesterolIBA 01/2018 - 10/2009
4	EnzymesIBA 02/2013 - 03/2007
3	Therapeutic UsesIBA 02/2024 - 12/2021
3	Glucosylceramidase (Glucocerebrosidase)IBA 01/2024 - 09/2007
3	NC009-1 compoundIBA 11/2023 - 01/2019
3	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2023 - 10/2016
3	CytokinesIBA 06/2021 - 08/2014
3	glycyrrhizae radix et rhizomaIBA 01/2021 - 01/2018
3	AntioxidantsIBA 11/2020 - 07/2017
3	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 10/2020 - 10/2016
3	Lactulose (Duphalac)FDA LinkGeneric 01/2020 - 05/2015
3	Peptide Initiation Factors (Initiation Factor)IBA 01/2020 - 03/2010
3	MelibioseIBA 01/2020 - 05/2015
3	UbiquitinIBA 01/2019 - 08/2009
3	ImmunosorbentsIBA 02/2013 - 05/2007
3	HaptoglobinsIBA 02/2013 - 05/2007
3	Phosphotransferases (Kinase)IBA 01/2013 - 06/2006
3	Leucine (L-Leucine)FDA Link 01/2013 - 06/2006
2	coumarinIBA 11/2023 - 01/2021
2	Chalcone (Benzalacetophenone)IBA 11/2023 - 01/2021
2	Prednisolone (Predate)FDA LinkGeneric 07/2023 - 11/2006
2	ApolipoproteinsIBA 01/2023 - 10/2009
2	Carrier Proteins (Binding Protein)IBA 01/2023 - 10/2022
2	AnticoagulantsIBA 01/2022 - 01/2022
2	Galectin 3 (LGALS3)IBA 11/2021 - 01/2019
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2021 - 01/2016
2	Creatine Kinase (Creatine Phosphokinase)IBA 01/2021 - 10/2004
2	Liposomes (Liposome)IBA 10/2020 - 10/2016
2	HLA-DR Antigens (HLA-DR)IBA 01/2020 - 01/2020
2	Apolipoproteins E (ApoE)IBA 01/2019 - 10/2009
2	Vitamin A (Retinol)FDA LinkGeneric 10/2018 - 12/2011
2	Vitamin E FDA LinkGeneric 10/2018 - 12/2011
2	Mitochondrial DNA (mtDNA)IBA 01/2018 - 12/2003
2	GuanineIBA 11/2017 - 11/2015
2	Adenine FDA LinkGeneric 11/2017 - 11/2015
2	CytosineIBA 11/2017 - 11/2015
2	Huntingtin ProteinIBA 11/2017 - 01/2016
2	Matrix Metalloproteinase 9 (Gelatinase B)IBA 02/2016 - 01/2015
2	Matrix Metalloproteinases (MMPs)IBA 02/2016 - 01/2015
2	TrehalaseIBA 01/2016 - 05/2015
2	TrehaloseIBA 01/2016 - 05/2015
2	Purinergic P1 Receptors (Adenosine Receptor)IBA 11/2015 - 08/2009
2	Protein Kinases (Protein Kinase)IBA 09/2015 - 10/2012
2	AtaxinsIBA 01/2013 - 02/2009
2	Urea (Carbamide)FDA LinkGeneric 08/2009 - 03/2007
2	LuciferasesIBA 05/2009 - 01/2009

Therapy/Procedure

8	Therapeutics 10/2022 - 03/2011
2	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/2019 - 01/2016
2	Gastrectomy 12/2017 - 10/2017